| Title: | The Parameter Converter of the Pharmacokinetic Models |
|---|---|
| Description: | Pharmacokinetics is the study of drug absorption, distribution, metabolism, and excretion. The pharmacokinetics model explains that how the drug concentration change as the drug moves through the different compartments of the body. For pharmacokinetic modeling and analysis, it is essential to understand the basic pharmacokinetic parameters. All parameters are considered, but only some of parameters are used in the model. Therefore, we need to convert the estimated parameters to the other parameters after fitting the specific pharmacokinetic model. This package is developed to help this converting work. For more detailed explanation of pharmacokinetic parameters, see "Gabrielsson and Weiner" (2007), "ISBN-10: 9197651001"; "Benet and Zia-Amirhosseini" (1995) <DOI: 10.1177/019262339502300203>; "Mould and Upton" (2012) <DOI: 10.1038/psp.2012.4>; "Mould and Upton" (2013) <DOI: 10.1038/psp.2013.14>. |
| Authors: | Eun-Kyung Lee, Hye-sun Cho |
| Maintainer: | Eun-Kyung Lee <[email protected]> |
| License: | GPL (>= 2) |
| Version: | 1.5 |
| Built: | 2024-12-12 03:10:11 UTC |
| Source: | https://github.com/cran/PKconverter |
Calculate pharmacokinetic parameters with parameters (A and alpha) in one compartment model "Aexp(-alpha)"
OneComp_Coefficient_Exponent(A,alpha,A.sd=NA,alpha.sd=NA, covar=c(Aalpha=NA),...)OneComp_Coefficient_Exponent(A,alpha,A.sd=NA,alpha.sd=NA, covar=c(Aalpha=NA),...)
A |
parameter in one compartment model "Aexp(-alpha)" |
alpha |
parameter in one compartment model "Aexp(-alpha)" |
A.sd |
standard error of A |
alpha.sd |
standard error of alpha |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
OneComp_Coefficient_Exponent(A=0.125,alpha=0.5,A.sd=0.002,alpha.sd=0.009)OneComp_Coefficient_Exponent(A=0.125,alpha=0.5,A.sd=0.002,alpha.sd=0.009)
Calculate pharmacokinetic parameters with volume of distribution (V1) and clearance (Cl1)
OneComp_Volume_Clearance(V1,Cl1,V1.sd=NA,Cl1.sd=NA, covar=c(V1Cl1=NA),...)OneComp_Volume_Clearance(V1,Cl1,V1.sd=NA,Cl1.sd=NA, covar=c(V1Cl1=NA),...)
V1 |
The volume of distribution of compartment 1 |
Cl1 |
Clearance from compartment 1 |
V1.sd |
standard error of V1 |
Cl1.sd |
standard error of Cl1 |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
Gabrielsson and Weiner(2006) Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Swedish Academy of Pharmaceutical Sciences.
OneComp_Volume_Clearance(V1=8,Cl1=4,V1.sd=0.01,Cl1.sd=0.01)OneComp_Volume_Clearance(V1=8,Cl1=4,V1.sd=0.01,Cl1.sd=0.01)
Calculate pharmacokinetic parameters with clearance (Cl1) and half-life (t_alpha)
OneComp_Volume_Clearance_HalfLife(Cl1,t_alpha, Cl1.sd=NA,t_alpha.sd=NA,covar=c(Cl1talpha=NA),...)OneComp_Volume_Clearance_HalfLife(Cl1,t_alpha, Cl1.sd=NA,t_alpha.sd=NA,covar=c(Cl1talpha=NA),...)
Cl1 |
Clearance from compartment 1 |
t_alpha |
half life of compartment 1 |
Cl1.sd |
standard error of Cl1 |
t_alpha.sd |
standard error of t_alpha |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
OneComp_Volume_Clearance_HalfLife(Cl1=4,t_alpha=0.568, Cl1.sd=0.01,t_alpha.sd=0.0003)OneComp_Volume_Clearance_HalfLife(Cl1=4,t_alpha=0.568, Cl1.sd=0.01,t_alpha.sd=0.0003)
Calculate pharmacokinetic parameters with volume of distribution(V1) and parameter (alpha) in the model "Aexp(-alpha)"
OneComp_Volume_Exponent(V1,alpha,V1.sd=NA,alpha.sd=NA, covar=c(V1alpha=NA),...)OneComp_Volume_Exponent(V1,alpha,V1.sd=NA,alpha.sd=NA, covar=c(V1alpha=NA),...)
V1 |
The volume of distribution of compartment 1 |
alpha |
parameter in one compartment model "Aexp(-alpha)" |
V1.sd |
standard error of V1 |
alpha.sd |
standard error of A |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
OneComp_Volume_Exponent(V1=8,alpha=0.5,V1.sd=0.01,alpha.sd=0.001)OneComp_Volume_Exponent(V1=8,alpha=0.5,V1.sd=0.01,alpha.sd=0.001)
Calculate pharmacokinetic parameters with volume of distribution (V1) and elimination rate constant (k10)
OneComp_Volume_RateConstant(V1,k10, V1.sd=NA,k10.sd=NA,covar=c(V1k10=0),...)OneComp_Volume_RateConstant(V1,k10, V1.sd=NA,k10.sd=NA,covar=c(V1k10=0),...)
V1 |
The volume of distribution of compartment 1 |
k10 |
elimination rate constant |
V1.sd |
standard error of V1 |
k10.sd |
standard error of k10 |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
OneComp_Volume_RateConstant(V1=8,k10=0.5,V1.sd=0.01,k10.sd=0.002)OneComp_Volume_RateConstant(V1=8,k10=0.5,V1.sd=0.01,k10.sd=0.002)
Pharmacokinetics is the study of drug absorption, distribution, metabolism, and excretion. The pharmacokinetics model explains that how the drug concentration change as the drug moves through the different compartments of the body. For pharmacokinetic modeling and analysis, it is essential to understand the basic pharmacokinetic parameters. All parameters are considered, but only some of parameters are used in the model. Therefore,we need to convert the estimated parameters to the other parameters after fitting the specific pharmacokinetic model.
PKconverterApp()PKconverterApp()
#PKconverterApp()#PKconverterApp()
Calculate pharmacokinetic parameters with parameters (A, B, C, alpha, beta, and gamma) in two compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"
ThreeComp_Coefficient_Exponent(A,B,C,alpha,beta,gamma,A.sd=NA, B.sd=NA,C.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA, covar=c(AB=NA,AC=NA,Aalpha=NA,Abeta=NA,Agamma=NA,BC=NA,Balpha=NA, Bbeta=NA,Bgamma=NA,Calpha=NA,Cbeta=NA,Cgamma=NA,alphabeta=NA, alphagamma=NA,betagamma=NA),...)ThreeComp_Coefficient_Exponent(A,B,C,alpha,beta,gamma,A.sd=NA, B.sd=NA,C.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA, covar=c(AB=NA,AC=NA,Aalpha=NA,Abeta=NA,Agamma=NA,BC=NA,Balpha=NA, Bbeta=NA,Bgamma=NA,Calpha=NA,Cbeta=NA,Cgamma=NA,alphabeta=NA, alphagamma=NA,betagamma=NA),...)
A |
parameter in one compartment model "Aexp(-alpha)" |
B |
parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)" |
C |
parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)" |
alpha |
parameter in one compartment model "Aexp(-alpha)" |
beta |
parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)" |
gamma |
parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)" |
A.sd |
standard error of A |
B.sd |
standard error of B |
C.sd |
standard error of C |
alpha.sd |
standard error of alpha |
beta.sd |
standard error of beta |
gamma.sd |
standard error of gamma |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
ThreeComp_Coefficient_Exponent(A=12.2,B=3.76,C=1.44, alpha=0.870,beta=0.12,gamma=0.013, A.sd=0.2,B.sd=0.005,C.sd=0.0005, alpha.sd=0.009,beta.sd=0.006,gamma.sd=0.00005)ThreeComp_Coefficient_Exponent(A=12.2,B=3.76,C=1.44, alpha=0.870,beta=0.12,gamma=0.013, A.sd=0.2,B.sd=0.005,C.sd=0.0005, alpha.sd=0.009,beta.sd=0.006,gamma.sd=0.00005)
Calculate pharmacokinetic parameters with volume of distributions (V1, V2 and V3) and clearances (Cl1, Cl2, and Cl3)
ThreeComp_Volume_Clearance(V1,V2,V3,Cl1,Cl2,Cl3, V1.sd=NA,V2.sd=NA,V3.sd=NA, Cl1.sd=NA,Cl2.sd=NA,Cl3.sd=NA, covar=c(V1V2=NA,V1V3=NA,V1Cl1=NA, V1Cl2=NA,V1Cl3=NA,V2V3=NA,V2Cl1=NA,V2Cl2=NA,V2Cl3=NA, V3Cl1=NA,V3Cl2=NA,V3Cl3=NA,Cl1Cl2=NA,Cl1Cl3=NA,Cl2Cl3=NA),...)ThreeComp_Volume_Clearance(V1,V2,V3,Cl1,Cl2,Cl3, V1.sd=NA,V2.sd=NA,V3.sd=NA, Cl1.sd=NA,Cl2.sd=NA,Cl3.sd=NA, covar=c(V1V2=NA,V1V3=NA,V1Cl1=NA, V1Cl2=NA,V1Cl3=NA,V2V3=NA,V2Cl1=NA,V2Cl2=NA,V2Cl3=NA, V3Cl1=NA,V3Cl2=NA,V3Cl3=NA,Cl1Cl2=NA,Cl1Cl3=NA,Cl2Cl3=NA),...)
V1 |
The volume of distribution of compartment 1 |
V2 |
The volume of distribution of compartment 2 |
V3 |
The volume of distribution of compartment 3 |
Cl1 |
Clearance from compartment 1 |
Cl2 |
Clearance from compartment 2 |
Cl3 |
Clearance from compartment 3 |
V1.sd |
standard error of V1 |
V2.sd |
standard error of V2 |
V3.sd |
standard error of V3 |
Cl1.sd |
standard error of Cl1 |
Cl2.sd |
standard error of Cl2 |
Cl3.sd |
standard error of Cl3 |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
ThreeComp_Volume_Clearance(V1=10,V2=100,V3=1000,Cl1=3,Cl2=2,Cl3=1, V1.sd=0.01,V2.sd=0.1,V3.sd=1,Cl1.sd=0.01,Cl2.sd=0.01,Cl3.sd=0.01)ThreeComp_Volume_Clearance(V1=10,V2=100,V3=1000,Cl1=3,Cl2=2,Cl3=1, V1.sd=0.01,V2.sd=0.1,V3.sd=1,Cl1.sd=0.01,Cl2.sd=0.01,Cl3.sd=0.01)
Calculate pharmacokinetic parameters with volume of distributions (Vd and V1), clearance (Cl1) and half-lives (t_alpha, t_beta, and t_gamma)
ThreeComp_Volume_Clearance_HalfLife(V1,Vd,Cl1,t_alpha,t_beta,t_gamma, V1.sd=NA,Vd.sd=NA,Cl1.sd=NA,t_alpha.sd=NA,t_beta.sd=NA,t_gamma.sd=NA, covar=c(V1Vd=NA,V1Cl1=NA,V1talpha=NA,V1tbeta=NA,V1tgamma=NA,VdCl1=NA, Vdtalpha=NA,Vdtbeta=NA,Vdtgamma=NA,Cl1talpha=NA,Cl1tbeta=NA, Cl1tgamma=NA,talphatbeta=NA,talphatgamma=NA,tbetatgamma=NA),...)ThreeComp_Volume_Clearance_HalfLife(V1,Vd,Cl1,t_alpha,t_beta,t_gamma, V1.sd=NA,Vd.sd=NA,Cl1.sd=NA,t_alpha.sd=NA,t_beta.sd=NA,t_gamma.sd=NA, covar=c(V1Vd=NA,V1Cl1=NA,V1talpha=NA,V1tbeta=NA,V1tgamma=NA,VdCl1=NA, Vdtalpha=NA,Vdtbeta=NA,Vdtgamma=NA,Cl1talpha=NA,Cl1tbeta=NA, Cl1tgamma=NA,talphatbeta=NA,talphatgamma=NA,tbetatgamma=NA),...)
V1 |
The volume of distribution of compartment 1 |
Vd |
Total volume of distributions |
Cl1 |
Clearance from compartment 1 |
t_alpha |
half life of compartment 1 |
t_beta |
half life of compartment 2 |
t_gamma |
half life of compartment 3 |
V1.sd |
standard error of V1 |
Vd.sd |
standard error of Vd |
Cl1.sd |
standard error of Cl1 |
t_alpha.sd |
standard error of t_alpha |
t_beta.sd |
standard error of t_beta |
t_gamma.sd |
standard error of t_gamma |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
ThreeComp_Volume_Clearance_HalfLife(V1=5,Vd=1110,Cl1=3, t_alpha=1.142,t_beta=52.2,t_gamma=931, V1.sd=0.01,Vd.sd=20,Cl1.sd=0.01, t_alpha.sd=0.002,t_beta.sd=0.5,t_gamma.sd=5.6)ThreeComp_Volume_Clearance_HalfLife(V1=5,Vd=1110,Cl1=3, t_alpha=1.142,t_beta=52.2,t_gamma=931, V1.sd=0.01,Vd.sd=20,Cl1.sd=0.01, t_alpha.sd=0.002,t_beta.sd=0.5,t_gamma.sd=5.6)
Calculate pharmacokinetic parameters with volume of distribution(V1), transfer rate constant (k12 and k31), and parameters (alpha, beta and gamma) in the model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"
ThreeComp_Volume_Exponent(V1,alpha,beta,gamma,k21,k31, V1.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA,k21.sd=NA,k31.sd=NA, covar=c(V1alpha=NA,V1beta=NA,V1gamma=NA,V1k21=NA,V1k31=NA, alphabeta=NA,alphagamma=NA,alphak21=NA,alphak31=NA, betagamma=NA,betak21=NA,betak31=NA,gammak21=NA,gammak31=NA, k21k31=NA),...)ThreeComp_Volume_Exponent(V1,alpha,beta,gamma,k21,k31, V1.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA,k21.sd=NA,k31.sd=NA, covar=c(V1alpha=NA,V1beta=NA,V1gamma=NA,V1k21=NA,V1k31=NA, alphabeta=NA,alphagamma=NA,alphak21=NA,alphak31=NA, betagamma=NA,betak21=NA,betak31=NA,gammak21=NA,gammak31=NA, k21k31=NA),...)
V1 |
The volume of distribution of compartment 1 |
alpha |
parameter in one compartment model "Aexp(-alpha)" |
beta |
parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)" |
gamma |
parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)" |
k21 |
transfer rate constants from compartment 2 to compartment 1 |
k31 |
transfer rate constants from compartment 3 to compartment 1 |
V1.sd |
standard error of V1 |
alpha.sd |
standard error of alpha |
beta.sd |
standard error of beta |
gamma.sd |
standard error of gamma |
k21.sd |
standard error of k21 |
k31.sd |
standard error of k31 |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
ThreeComp_Volume_Exponent(V1=10,alpha=0.6, beta=0.013, gamma=0.00074, k21=0.02, k31=0.001, V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005, gamma.sd=0.000002, k21.sd=0.0006,k31.sd=0.0000005)ThreeComp_Volume_Exponent(V1=10,alpha=0.6, beta=0.013, gamma=0.00074, k21=0.02, k31=0.001, V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005, gamma.sd=0.000002, k21.sd=0.0006,k31.sd=0.0000005)
Calculate pharmacokinetic parameters with volume of distribution (V1), elimination rate constant (k10), and transter rate constants (k12, k13, k21, and k31)
ThreeComp_Volume_RateConstant(V1,k10,k12,k13,k21,k31, V1.sd=NA,k10.sd=NA,k12.sd=NA, k13.sd=NA,k21.sd=NA,k31.sd=NA,covar=c(V1k10=NA,V1k12=NA,V1k13=NA, V1k21=NA,V1k31=NA,k10k12=NA,k10k13=NA,k10k21=NA,k10k31=NA, k12k13=NA,k12k21=NA,k12k31=NA,k13k21=NA,k13k31=NA,k21k31=NA),...)ThreeComp_Volume_RateConstant(V1,k10,k12,k13,k21,k31, V1.sd=NA,k10.sd=NA,k12.sd=NA, k13.sd=NA,k21.sd=NA,k31.sd=NA,covar=c(V1k10=NA,V1k12=NA,V1k13=NA, V1k21=NA,V1k31=NA,k10k12=NA,k10k13=NA,k10k21=NA,k10k31=NA, k12k13=NA,k12k21=NA,k12k31=NA,k13k21=NA,k13k31=NA,k21k31=NA),...)
V1 |
The volume of distribution of compartment 1 |
k10 |
elimination rate constant |
k12 |
transfer rate constants from compartment 1 to compartment 2 |
k13 |
transfer rate constants from compartment 1 to compartment 3 |
k21 |
transfer rate constants from compartment 2 to compartment 1 |
k31 |
transfer rate constants from compartment 3 to compartment 1 |
V1.sd |
standard error of V1 |
k10.sd |
standard error of k10 |
k12.sd |
standard error of k12 |
k13.sd |
standard error of k13 |
k21.sd |
standard error of k21 |
k31.sd |
standard error of k31 |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
ThreeComp_Volume_RateConstant(V1=10,k10=0.3,k12=0.2,k13=0.1,k21=0.02, k31=0.001,V1.sd=0.1,k10.sd=0.002,k12.sd=0.001, k13.sd=0.0005,k21.sd=0.0005,k31.sd=0.000005)ThreeComp_Volume_RateConstant(V1=10,k10=0.3,k12=0.2,k13=0.1,k21=0.02, k31=0.001,V1.sd=0.1,k10.sd=0.002,k12.sd=0.001, k13.sd=0.0005,k21.sd=0.0005,k31.sd=0.000005)
Calculate pharmacokinetic parameters with parameters (A, B, alpha and beta) in two compartment model "Aexp(-alpha)+Bexp(-beta)"
TwoComp_Coefficient_Exponent(A,B,alpha,beta, A.sd=NA,B.sd=NA,alpha.sd=NA,beta.sd=NA, covar=c(AB=NA,Aalpha=NA,Abeta=NA,Balpha=NA,Bbeta=NA,alphabeta=NA),...)TwoComp_Coefficient_Exponent(A,B,alpha,beta, A.sd=NA,B.sd=NA,alpha.sd=NA,beta.sd=NA, covar=c(AB=NA,Aalpha=NA,Abeta=NA,Balpha=NA,Bbeta=NA,alphabeta=NA),...)
A |
parameter in one compartment model "Aexp(-alpha)" |
B |
parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)" |
alpha |
parameter in one compartment model "Aexp(-alpha)" |
beta |
parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)" |
A.sd |
standard error of A |
B.sd |
standard error of B |
alpha.sd |
standard error of alpha |
beta.sd |
standard error of beta |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
TwoComp_Coefficient_Exponent(A=0.196,B=0.0036,alpha=1.221,beta=0.0287, A.sd=0.002,B.sd=0.00005,alpha.sd=0.09,beta.sd=0.0006)TwoComp_Coefficient_Exponent(A=0.196,B=0.0036,alpha=1.221,beta=0.0287, A.sd=0.002,B.sd=0.00005,alpha.sd=0.09,beta.sd=0.0006)
Calculate pharmacokinetic parameters with volume of distributions (V1 and V2) and clearances (Cl1 and Cl2)
TwoComp_Volume_Clearance(V1,V2,Cl1,Cl2, V1.sd=NA,V2.sd=NA,Cl1.sd=NA,Cl2.sd=NA, covar=c(V1V2=0,V1Cl1=0,V1Cl2=0, V2Cl1=0,V2Cl2=0,Cl1Cl2=0),...)TwoComp_Volume_Clearance(V1,V2,Cl1,Cl2, V1.sd=NA,V2.sd=NA,Cl1.sd=NA,Cl2.sd=NA, covar=c(V1V2=0,V1Cl1=0,V1Cl2=0, V2Cl1=0,V2Cl2=0,Cl1Cl2=0),...)
V1 |
The volume of distribution of compartment 1 |
V2 |
The volume of distribution of compartment 2 |
Cl1 |
Clearance from compartment 1 |
Cl2 |
Clearance from compartment 2 |
V1.sd |
standard error of V1 |
V2.sd |
standard error of V2 |
Cl1.sd |
standard error of Cl1 |
Cl2.sd |
standard error of Cl2 |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
TwoComp_Volume_Clearance(V1=5,V2=50,Cl1=3.5,Cl2=2.5, V1.sd=0.01,V2.sd=0.1,Cl1.sd=0.01,Cl2.sd=0.01)TwoComp_Volume_Clearance(V1=5,V2=50,Cl1=3.5,Cl2=2.5, V1.sd=0.01,V2.sd=0.1,Cl1.sd=0.01,Cl2.sd=0.01)
Calculate pharmacokinetic parameters with volume of distribution(V1), clearance (Cl1) and half-lives (t_alpha and t_beta)
TwoComp_Volume_Clearance_HalfLife(V1,Cl1,t_alpha,t_beta, V1.sd=NA,Cl1.sd=NA,t_alpha.sd=NA, t_beta.sd=NA,covar=c(V1Cl1=NA,V1talpha=NA,V1tbeta=NA,Cl1talpha=NA, Cl1tbeta=NA,talphatbeta=NA),...)TwoComp_Volume_Clearance_HalfLife(V1,Cl1,t_alpha,t_beta, V1.sd=NA,Cl1.sd=NA,t_alpha.sd=NA, t_beta.sd=NA,covar=c(V1Cl1=NA,V1talpha=NA,V1tbeta=NA,Cl1talpha=NA, Cl1tbeta=NA,talphatbeta=NA),...)
V1 |
The volume of distribution of compartment 1 |
Cl1 |
Clearance from compartment 1 |
t_alpha |
half life of compartment 1 |
t_beta |
half life of compartment 2 |
V1.sd |
standard error of V1 |
Cl1.sd |
standard error of Cl1 |
t_alpha.sd |
standard error of t_alpha |
t_beta.sd |
standard error of t_beta |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
TwoComp_Volume_Clearance_HalfLife(V1=5,Cl1=3.5,t_alpha=0.568,t_beta=24.2, V1.sd=0.01,Cl1.sd=0.01,t_alpha.sd=0.002,t_beta.sd=0.5)TwoComp_Volume_Clearance_HalfLife(V1=5,Cl1=3.5,t_alpha=0.568,t_beta=24.2, V1.sd=0.01,Cl1.sd=0.01,t_alpha.sd=0.002,t_beta.sd=0.5)
Calculate pharmacokinetic parameters with volume of distribution(V1), transfer rate constant (k12), and parameters (alpha and beta) in the model "Aexp(-alpha)+Bexp(-beta)"
TwoComp_Volume_Exponent(V1,alpha,beta,k21,V1.sd=NA, alpha.sd=NA,beta.sd=NA,k21.sd=NA, covar=c(V1alpha=NA,V1beta=NA,V1k21=NA,alphabeta=NA, alphak21=NA,betak21=NA),...)TwoComp_Volume_Exponent(V1,alpha,beta,k21,V1.sd=NA, alpha.sd=NA,beta.sd=NA,k21.sd=NA, covar=c(V1alpha=NA,V1beta=NA,V1k21=NA,alphabeta=NA, alphak21=NA,betak21=NA),...)
V1 |
The volume of distribution of compartment 1 |
alpha |
parameter in one compartment model "Aexp(-alpha)" |
beta |
parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)" |
k21 |
transfer rate constants from compartment 2 to compartment 1 |
V1.sd |
standard error of V1 |
alpha.sd |
standard error of alpha |
beta.sd |
standard error of beta |
k21.sd |
standard error of k21 |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
TwoComp_Volume_Exponent(V1=5,alpha=1.221, beta=0.029, k21=0.05, V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005,k21.sd=0.0006)TwoComp_Volume_Exponent(V1=5,alpha=1.221, beta=0.029, k21=0.05, V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005,k21.sd=0.0006)
Calculate pharmacokinetic parameters with volume of distribution (V1), elimination rate constant (k10), and transter rate constants (k12, k21)
TwoComp_Volume_RateConstant(V1,k10,k12,k21, V1.sd=NA,k10.sd=NA,k12.sd=NA,k21.sd=NA, covar=c(V1k10=NA,V1k12=NA,V1k21=NA, k10k12=NA,k10k21=NA,k12k21=NA),...)TwoComp_Volume_RateConstant(V1,k10,k12,k21, V1.sd=NA,k10.sd=NA,k12.sd=NA,k21.sd=NA, covar=c(V1k10=NA,V1k12=NA,V1k21=NA, k10k12=NA,k10k21=NA,k12k21=NA),...)
V1 |
The volume of distribution of compartment 1 |
k10 |
elimination rate constant |
k12 |
transfer rate constants from compartment 1 to compartment 2 |
k21 |
transfer rate constants from compartment 2 to compartment 1 |
V1.sd |
standard error of V1 |
k10.sd |
standard error of k10 |
k12.sd |
standard error of k12 |
k21.sd |
standard error of k21 |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
TwoComp_Volume_RateConstant(V1=5,k10=0.7,k12=0.5,k21=0.05, V1.sd=0.01,k10.sd=0.002,k12.sd=0.001,k21.sd=0.0005)TwoComp_Volume_RateConstant(V1=5,k10=0.7,k12=0.5,k21=0.05, V1.sd=0.01,k10.sd=0.002,k12.sd=0.001,k21.sd=0.0005)